In Vivo Blockade of Tumor Necrosis Factor-a Accelerates Functional Endothelial Recovery After Balloon Angioplasty
نویسندگان
چکیده
Recovery After Balloon Angioplasty Accelerates Functional Endothelial α In Vivo Blockade of Tumor Necrosis FactorPrint ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2001 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/hc4001.098046 2001;104:1754-1756 Circulation. http://circ.ahajournals.org/content/104/15/1754 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
In vivo blockade of tumor necrosis factor-alpha accelerates functional endothelial recovery after balloon angioplasty.
BACKGROUND Tumor necrosis factor-alpha (TNF) is expressed locally in arteries at sites of balloon injury. In vitro studies have shown that TNF inhibits cell cycle progression and induces apoptosis in endothelial cells. Accordingly, we performed a series of experiments to test the hypothesis that inhibiting TNF could accelerate endothelial recovery after angioplasty. METHODS AND RESULTS TNF so...
متن کاملBlockade of Hypoxia: The Impact on Tumor Growth in an Experimental Tumor Model
Background: Tumor microenvironment is an active factor participating in immunoregulation, thereby preventing immunosurveillance and limiting the efficacy of anticancer therapies. Hypoxia as a major characteristic of solid tumors causes the expression of Hypoxia-Inducible Factor-1α (HIF-1α). This is a transcription factor that mediates hypoxic responses of tumor cells and involves in the express...
متن کاملIn vivo immunotherapy of lung cancer using cross-species reactive vascular endothelial growth factor nanobodies
Objective(s): Lung cancer is the main leading cause of cancer death worldwide. Angiogenesis is the main step in proliferation and spreading of tumor cells. Targeting vascular endothelial growth factor (VEGF) is an effective approach for inhibition of cancer angiogenesis. Nanobodies (NBs) are a novel class of antibodies derived from the camel. Unique characteristics of Nbs like their small size ...
متن کاملEngineering the response to vascular injury: divergent effects of deregulated E2F1 expression on vascular smooth muscle cells and endothelial cells result in endothelial recovery and inhibition of neointimal growth.
Tumor necrosis factor-alpha (TNF-alpha) is expressed locally in the vessel wall after angioplasty and induces growth arrest and apoptosis in endothelial cells (ECs), thereby delaying reendothelialization. Prior studies have shown that direct antagonism of TNF-alpha, using a systemically administered soluble receptor, can enhance endothelial recovery and reduce neointimal thickening. These studi...
متن کاملDivergent Effects of Deregulated E2F1 Expression on Vascular Smooth Muscle Cells and Endothelial Cells Results in Endothelial Recovery and Inhibition of Neointimal Growth
Tumor necrosis factor-a (TNF-a) is expressed locally in the vessel wall after angioplasty and induces growth arrest and apoptosis in endothelial cells (ECs), thereby delaying reendothelialization. Prior studies have shown that direct antagonism of TNF-a, using a systemically administered soluble receptor, can enhance endothelial recovery and reduce neointimal thickening. These studies have also...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2001